Methylsulfonylmethane (MSM) enters the body as a dietary sulfur associated with the amino acids. In clinical tests, use of MSM produced significant relief of pain and stiffness along with reduced swelling and inflammation. MSM prevents pressure build up in cells, permitting nutrients in and pushing toxins out. There is a positive synergistic effect on the building of healthier cells when MSM is taken in combination with Vitamin C. The combination of Glucosamine and Perna Canaliculus stimulates synovial fluid synthesis, as well as the production of essential connective tissues. Glucosamine returns viscosity to the synovial fluid and enhances its ability to carry the vital nutrients necessary to rebuild cartilage, insulate the bone from friction and cushion the joint in movement. Active Ingredient(s): Methylsulfonylmethane, Glucosamine HCl, Perna Canaliculus, Vitamin C Per tablet: MSM 800 mg Glucosamine hcl 500 mg Perna Caniculus 300 mg Vitamin C 10 mg Initial Administration: (4-6 week period) Pets 30-60 lbs. 2 tablets daily Pets 60-100 lbs. 3 tablets daily Pets over 100 lbs. 4 tablets daily Maintenance Administration: (After initial 6 week period) Pets under 60 lbs. may lower dosage by 1/2 tablet per month until maintenance level is achieved. Pets over 60 lbs. may lower dosage by 1 tablet per month until maintenance level is achieved.