Denamarin is a liver supplement for dogs or cats containing S-Adenosylmethionine (SAMe) and silybin. When liver function is compromised, the exact cause can often be difficult to determine. Supporting the liver, regardless of the cause, is essential if function is to be improved. Administering SAMe, which is found in Denamarin, has been shown to markedly increase liver glutathione levels2,3, a potent antioxidant formed when cats and dogs metabolize SAMe. The SAMe in Denamarin has also been shown to help protect liver cells from cell death4,5 and may help cell repair and regeneration.1 Denamarin also helps support your pet's liver through the administration of silybin. Silybin is the most active part of an extract from milk thistle known as silymarin. Silybin/silymarin has been shown to support liver function by acting as an antioxidant. Silybin also stimulates the flow of bile through the liver to aid in the digestion and absorption of nutrients from your pet's diet. Silybin also helps with liver cell regeneration and may enhance levels of glutathione, the liver's major “detoxifying” agent. Denamarin has no known side-effects and your veterinarian can evaluate the length of support needed through follow-up examinations, blood work, and/or other laboratory work. At home, you can watch for improvements in your pet's attitude, appetite, and activity level.